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34 Additionally, data from the 2-week and 12-week treatment phases of the study demonstrated an increased mean corpuscular volume, decreased mean corpuscular hemoglobin concentration, increased antioxidant capacity, and decreased markers of inflammation, hypercoagulability, adhesion, and serum erythropoietin level, suggesting potential pleiotropic salutary effects of PK activation in SCD

The issue is of course that it does this throughout the brain (think of a heavy, wet blanket)